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The effect of eight weeks of MICT training and Chlorogenic acid supplementation on GLP1 and DPP4 indices in inactive overweight women

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background: Overweight and obesity, which occur with an increase in body mass and fat volume in the body, are considered major health problems in today's sedentary and mechanized world, threatening the health of a wide range of societies, including young people, middle-aged people, and even children. This can lead to metabolic diseases such as diabetes and other physiological disorders by increasing inflammatory markers. For this reason, the purpose of this study was to investigate the effect of eight weeks of MICT training combined with chlorogenic acid supplementation on DPP4 and GLP1 markers in inactive overweight women. Methods: 40 inactive and overweight women with an age range (25-35 years) and a body mass index between 25 and 30 voluntarily participated in the present study. In this study, the subjects were randomly divided into four groups: MICT exercise group (n = 10),chlorogenic acid supplement group (n = 10),combined MICT exercise and chlorogenic acid supplement group (n = 10), and control group (n = 10). The exercise groups performed the exercises for eight weeks,three sessions per week, according to the desired protocol. The dependent variables were measured through blood sampling including 10 cc of blood from the brachial vein in fasting conditions and in a sitting position. One 400 mg chlorogenic acid supplement capsule was taken daily. Results: The study showed that the combination of MICT training and chlorogenic acid caused an increasing effect on the anti-inflammatory and blood sugar metabolism controller GLP1 index (p=0.0001) and a significant decreasing effect on the DPP4 index in overweight women (p=0.0001). Conclusion: The combination of MICT training and chlorogenic acid with a synergistic effect can play a significant role in reducing inflammatory markers and increasing anti-inflammatory markers in improving the metabolic status of overweight individuals.

Source: Exercise Physiology and Performance (EPP)

DOI: 10.71951/1226427/epp.202511301226427

Authors: Negin Bilghoosh, Sajad Arshadi, Ardeshir Zafari, Vahid Imanipour

Institutions: Islamic Azad University, Tehran, Islamic Azad University South Tehran Branch, Islamic Azad University of Zanjan, Islamic Azad University Central Tehran Branch

Language: English

Topic: Physical Activity and Health

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7214540979

FWCI:

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