Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts
Year: 2026
Type: article
Abstract: External exposome research offers opportunities to evaluate complex relationships between multiple environmental determinants of Alzheimer's disease and related dementias (ADRD). However, selecting specific exposure domains, identifying metrics, and downloading, processing, and managing big data are key challenges in translating the potential of exposome research into empirical data analyses. To overcome these issues, we have established a reproducible system that protects data privacy, setting the stage for an unparalleled examination of associations between environmental exposures and ADRD risk within an exposome framework. In this perspective, we provide a comprehensive guide, including examples, to linking natural, built, and social environment metrics to nationwide time-varying participants' residential address data. Further, as a proof of concept, we report descriptive statistics and spatial distribution of external exposome metrics across the contiguous United States in 2015. The external exposome can be securely and comprehensively characterized across multiple cohorts using this highly scalable approach.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.71841
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Awards: Neurodegenerative diseases and the role of green space: A deep learning assessment, Neurodegenerative diseases and the role of green space: A deep learning assessment, Race/ethnicity and Environmental Stressors: POtential drivers of Dementia and stroke inequities RESPOnD, Environmental Resources for Individual Cognitive Health/Resilience (EnRICH)
OpenAlex ID: W7214572302