Work

Iris metastasis as the first manifestation of metastatic endometrial adenocarcinoma

Year: 2026

Type: article

Abstract: Background Ocular metastases from endometrial adenocarcinoma are rare, particularly those involving the anterior uvea. Case Presentation We report the case of a 53-year-old woman in whom severe acute anterior uveitis was the first clinical manifestation of previously undiagnosed metastatic endometrial adenocarcinoma. Following partial resolution of the inflammatory process, an iridociliary lesion became clinically apparent, prompting systemic evaluation. Further investigation revealed an endometrial tumor with metastatic lymphadenopathy, and biopsy confirmed metastatic endometrioid adenocarcinoma. In the context of biopsy-proven metastatic disease and compatible ophthalmological findings, the iridociliary lesion was considered a presumed metastasis, allowing ocular biopsy to be avoided. The lesion completely regressed following systemic oncological treatment. Conclusion Anterior uveal metastasis may rarely represent the first clinical manifestation of metastatic endometrial adenocarcinoma. Recognition of atypical ocular presentations and multidisciplinary assessment may facilitate timely diagnosis and avoid unnecessary invasive ocular procedures.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2026.102225