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Synthesis of Semisaturated Polycycles via a Microwave-Promoted Iminyl Radical Cascade Cyclization

Year: 2026

Type: preprint

Abstract: A microwave-promoted iminyl radical cascade cyclization that furnishes semisaturated polycycles is reported. Competitive reduction was suppressed by lowering the reaction concentration. The protocol is simple and tolerates a wide range of O -aryloxime substrates, with those bearing an electron-withdrawing group on the participating aryl ring performing the best. The modular substrate synthesis renders the process useful for constructing compound libraries.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15009695/v1

Authors: Caleb J. Petersen, Joshua D. Morgan, Corbin D. Stratton, Tanner A. Trejo, Ethan P. Downing, Jonathan J. Barker, Steven L. Castle

Institution: Brigham Young University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, Brigham Young University, Division of Chemistry

Awards: G9000075419, No Catalyst Required: New Thermally-Promoted Transformations of Iminyl Radicals for the Synthesis of Complex Molecules

OpenAlex ID: W7214907004

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