Comparative Evaluation of the Phenolic Profiles of Salvia hydrangea DC. ex Benth. (Sage) Samples Collected from Different Locations in Iğdır Province by HPLC–DAD and Their Potential Applications in the Cosmetic and Health Sectors
Year: 2026
Type: article
Abstract: Salvia hydrangea DC. ex Benth. (sage) is an important medicinal and aromatic plant characterized by its rich phenolic composition and well-documented antioxidant, antimicrobial, and anti-inflammatory properties. In this study, the phenolic profiles of Salvia hydrangea DC. ex Benth. samples collected from Karaçomak and Asma villages in Iğdır Province, Türkiye, were determined using high-performance liquid chromatography coupled with a diode-array detector (HPLC–DAD). The chemical differences between the samples were evaluated through chemometric analyses, and the interactions of the major phenolic compounds with DNA were investigated using molecular docking analysis. The results revealed that rosmarinic acid was the predominant phenolic compound in both samples, while chlorogenic acid, catechin, quercetin, chrysin, o-coumaric acid, and naringin were also identified. The Karaçomak sample exhibited significantly higher total phenolic content and rosmarinic acid concentration than the Asma sample. Chemometric analyses successfully classified the samples according to their phenolic profiles, demonstrating a clear influence of geographical origin on their chemical composition. Molecular docking analysis showed that chrysin and rosmarinic acid exhibited binding free energies of −8.1 and −7.8 kcal/mol toward DNA, respectively. Chrysin primarily interacted with DNA through minor-groove binding supported by π–π stacking interactions, whereas rosmarinic acid displayed a strong binding mechanism stabilized by multiple hydrogen bonds and van der Waals interactions. These findings demonstrate that geographical origin is a determining factor influencing the phenolic composition of Salvia hydrangea DC. ex Benth. and highlight that phenolic-rich sage extracts represent promising natural bioactive resources for cosmetic, dermocosmetic, and healthcare applications.
Source: ICONTECH INTERNATIONAL JOURNAL
Institutions: Muğla University, Iğdır Üniversitesi, Batman University
Language: English
Subfield: Biochemistry (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7214910232