Work

Diminished Ovarian Reserve with Markedly Elevated BPA Exposure in One of Two Monozygotic Twin Sisters Married to Monozygotic Twin Brothers

Year: 2026

Type: preprint

Abstract: Background: Diminished ovarian reserve (DOR) in young women is commonly attributed to genetic factors; however, environmental endocrine-disrupting chemicals, particularly bisphenol A (BPA), have been increasingly implicated in ovarian dysfunction (1, 2, 4). Case: We report a unique case involving identical twin sisters married to identical twin brothers, minimising genetic, intrauterine, and partner-related confounding. One sister presented with infertility and DOR, while her genetically identical twin had preserved fertility. Environmental toxin analysis revealed a markedly elevated preconceptional urinary BPA level in the infertile woman, exceeding laboratory reference limits. In contrast, BPA concentrations in the other family members were within normal ranges. Conclusion: This uniquely controlled human model suggests that diminished ovarian reserve may not be explained solely by genetic aetiology; environmental endocrine-disrupting chemicals may contribute to ovarian reserve impairment at clinically meaningful exposure levels, underscoring the need for systematic investigation of such exposures (1–4).

Source: Research Square

DOI: 10.21203/rs.3.rs-11028225/v1

Authors: Hande Antep TÖRE, Rovshan JABBAROV, Murat BERKKANOĞLU, Hasan BULUT, Kevin COETZEE, Muhittin SERDAR, Kemal ÖZGÜR

Institutions: Antalya IVF, Atlas Üniversitesi, Antalya Bilim Üniversitesi, Antalya Bilim University, Acıbadem University

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7214930635

Cites: 9

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Related to: 10