Validation of the GastroIntestinal Dysfunction Score (GIDS): prospective observational multicentre study (GUTPHOS Study)
Year: 2026
Type: article
Study design: Observational Study
Abstract: The present multicentre, prospective cohort study of intensive care unit (ICU) patients aims to validate the recently developed Gastrointestinal Dysfunction Score (GIDS) against mortality, given the absence of gold standard for respective organ dysfunction assessment. Consecutive adult patients admitted to ICUs worldwide were included from 28 ICUs worldwide between January and August 2024, with a maximum of 120 patients per site during an eight-week study period. Patients were monitored daily from ICU admission to discharge or a maximum of seven days in the ICU. Cox proportional hazards models with time-dependent covariates were used for 28- and 90-day mortality, and C-statistics to evaluate relative contribution of GIDS added to SOFA total and SOFA subscores. Binary and ordinal logistic regression were used for parenteral nutrition (PN) and ICU dependency, respectively. In total, 2679 patients from 28 sites were included. The GIDS was associated with 28- and 90-day mortality when adjusted for total SOFA score or all SOFA subscores in the full cohort analysis ( n = 2629). In the small cohort where all the variables of the GIDS were available (both intra-abdominal pressure and gastric residual volumes measured, n = 311), it associated with 28-day, but not with 90-day mortality. Adding GIDS to SOFA score slightly improved the predictive value of the latter for 28- and 90-day mortality in the full cohort analysis (C-statistic from 0.826 to 0.835 and 0.765 to 0.773, respectively). Increasing GIDS was associated with greater PN use and fewer ICU-free days. The GIDS was successfully validated against mortality and is proposed for assessment of GI dysfunction as a part of multiple organ dysfunction. The study was registered on ClinicalTrials.gov (NCT05909722) on 18.06.2023.
Source: Critical Care
Authors: Annika Reintam Blaser, Merli Koitmäe, Arthur R. H. van Zanten, Oskar Appelberg, Yaseen M. Arabi, Varsha Asrani, Anca Balintescu, Guillaume Besch, Jonas Blixt, Giuliano Bolondi, Laura Borgstedt, Michael P. Casaer, Henri Cattier, Zhigang Chang, Samantha Cook, Antonella Cotoia, František Duška, Hans-Erik Ehrlich, Ligia C. Fonseca Höflinger, Ola Friman, Yao Fu, Kristina Fuest, Jan Gunst, Adi Hadzibegovic, Benjamin Hess, Claire-Anne Hurni, Bojan Jovanovic, Imre Kouw, Torben Krieger, Hongxiang Li, Rebecca Lindström, Juan C. Lopez-Delgado, Cecilia Inés Loudet, Liivi Maddison, Ramprasad Matsa, Daniela M. Moran, Karim Muhhamedjanov, Olivier Pantet, Bastian Pasieka, Giorgia Perini, Sirak Petros, Uroš Ristic, Raul M. Sanchez Leon, Stefan J. Schaller, Jovana Stanisavljevic, Joel Starkopf, Martin Sundström Rehal, Maria Theodorakopoulou, Greet Van den Berghe, Jacqueline Vilca Becerra, Anna-Liisa Voomets, Natalija Vukovic, Rebecka Rubenson Wahlin, Luping Wang, Yucong Wang, Linus Warner, Qin Wu, Pia Zetterqvist, Dong Zhang, Alice Efstathia Zouridaki, Martin Padar, GUTPHOS Study Group, Kadri Tamme, Vladislav Mihnovitš, Anna Pörings, Anna Grünewald, Max Melchers, Marianne Bouw, Yvonne Swaen, Yazir Alzoubi, Norah Alamrey, Liese Mebis, Philippe Huynen, Lies Langouche, Romain Bonnert, Viveka Hambäck Hellkvist, Kristina Kilsand, Francesca Casale, Anna Scholze, Amalia Boeriu, Alex Schimmel, Yuping Zhang, Bingkui Ren, Siying Chen, Shashank Danndhiganaahalli, Davide Correnti, Antonietta Basta, Lucia Distaso, Veronika Řehořová, Marie Chaloupecká, Markéta Kaupová, Maximilian Markus, Zakariya Bhuiyan, Stefania Stock, Youquan Wang, Lulu Sheng, Zhe Zhang, Marija Milenković, Stefan Stanković, Nebojša Brezić, Pamela Doti, Eric Mayor-Vazquez, Laura Almorin-Gonzalvez, Diego Contreras Bringas, Monica Tang, Milos Stepanović, Anita Vuković, Ivana Budić, Ott Maasikas, Maria Avgoulea, Evangelia Diogou, Konstantinos Kostoulas, Jing Yang, Manu Malbrain
Institutions: Luzerner Kantonsspital, University of Tartu, Ziekenhuis Gelderse Vallei, Wageningen University & Research, North Estonia Medical Centre, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, University of Auckland, Auckland City Hospital, Health New Zealand, Karolinska Institutet, Stockholm South General Hospital, Inserm, Centre Hospitalier Universitaire de Besançon, Soins intégrés, Nanomédecine, IA & Ingénierie pour la Santé, Université Marie et Louis Pasteur, Karolinska University Hospital, Ospedale “M. Bufalini” di Cesena, TUM Klinikum, Technical University of Munich, Universitair Ziekenhuis Leuven, KU Leuven, University of Lausanne, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Hospital, University Hospitals of North Midlands NHS Trust, Royal Stoke University Hospital, Ospedali Riuniti di Foggia, Charles University, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité – Universitätsmedizin Berlin, First Hospital of Jilin University, Univerzitetski Klinički Centar Srbije, Centre Hospitalier Universitaire Vaudois, Hospital Clínic de Barcelona, Universidad Nacional de La Plata, Keele University, Houston Methodist, University Hospital Leipzig, University of Nis, Medical University of Vienna, Tartu University Hospital, KAT General Hospital of Attica, Sichuan University, West China Hospital of Sichuan University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
Award: G9000844073
OpenAlex ID: W7214949356