Work

Electrical stimulation elicits space- and parameter-dependent spiking responses in human cortical organoids

Year: 2026

Type: article

Abstract: Cortical stimulation is routinely tuned to probe, enhance, and suppress targeted brain circuits, yet parameter selection has historically relied largely on empirical experience. Recent studies have begun addressing this limitation by systematically investigating how electrical stimulation (ES) parameters shape regional and global brain responses [1,2]. However, the effects of ES parameters at the single-neuron level in humans remain elusive, as current knowledge relies primarily on data from pathological conditions, animal and ex-vivo models, and traditional neuronal cultures [3].

Source: Brain stimulation

DOI: 10.1016/j.brs.2026.103222