Supplemental Material for: Clinical Course and Prognosis of the Global Leadership Initiative on Malnutrition-defined Malnutrition in Critically Ill Patients with Sepsis: A Multicenter Prospective Observational Study
Year: 2026
Type: supplementary-materials
Abstract: Introduction: Sepsis is a critical condition with a high nutritional risk and mortality. Although the Global Leadership Initiative on Malnutrition (GLIM) criteria have been proposed for diagnosing malnutrition, their clinical relevance in sepsis remains unclear. Therefore, we conducted a descriptive study on GLIM-defined malnutrition in intensive care unit (ICU) patients with sepsis to investigate its clinical course and prognosis. Methods: This was a multicenter prospective study conducted at 15 centers. Malnutrition was identified at ICU admission when both phenotypic and etiologic criteria were present. The primary outcome was a composite of in-hospital mortality or a decline in activities of daily living (Barthel Index <90) at discharge. Secondary outcomes included ICU length of stay, use of parenteral nutrition, and days to achievement of each ICU Mobility Scale level. Results: Among 254 patients, 106 (41.7%) had malnutrition. The malnutrition group showed a significantly higher occurrence of the composite of in-hospital mortality and Barthel Index <90 (76.4% vs. 64.2%, p=0.04) and had significantly longer ICU stays (7 vs. 5, p=0.001). Total nutrition delivery did not significantly differ between groups, while a higher percentage of patients in the malnutrition group received parenteral nutrition (57.6% vs. 43.2%, p=0.02). Significant delays in achieving higher mobility levels were observed in the malnutrition group. Conclusions: GLIM-defined malnutrition in patients with sepsis was significantly associated with the composite outcome of in-hospital mortality or Barthel Index <90 at discharge. These results suggest the clinical importance of an early GLIM assessment after ICU admission.
Source: Figshare
Authors: figshare admin karger, Tomoka Miyagi, Minoru Yoshida, Naoki Kanda, Shinya Suganuma, Akane Kariya, Yusuke Hoshi, Takahiro Fujita, Kensei Togo, Tomoaki Obata, Kenzo Ishii, Katsuyuki Abe, Chihiro Sato, Yoshifumi Heshiki, Daisetsu Yasumura, Shizuko Gomi, Masafumi Takahashi, Takashi Hongo, Keiji Sakurai, Miho Nishihara, Yuko Matsuda, Kiyota Chinen, Akiko Arai, Michihiro Maeda, Yuhei Irie, Hiroshi Kamijo, Kana Hosokawa, Daisuke Kasugai, Michiko Higashi, Ayaka Matsuoka, Hirotaka Ogawa, Yuichi Araki, Kenji Oike, Daigo Shimakura, Hajime Katsukawa, Toru Kotani, Takayuki Ogura, Keibun Liu, Kensuke Nakamura
Institution: Karger Publishers (Switzerland)
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7214977296