Work

Seasonal malaria chemoprevention effectiveness and drug resistance in Plasmodium falciparum: a matched parallel cohort study; Kenya

Year: 2026

Type: article

Abstract: Objective: To evaluate seasonal malaria chemoprevention with sulfadoxine-pyrimethamine and amodiaquine in a semi-nomadic community in north-western Kenya, and to examine the relationship between parasite resistance and breakthrough infections. Methods: gene substitutions associated with sulfadoxine-pyrimethamine resistance. Findings: gene mutations were more common in the intervention than non-intervention cohort and became more frequent as the number of treatment cycles increased. Conclusion: Seasonal malaria chemoprevention with sulfadoxine-pyrimethamine and amodiaquine was associated with substantial protection against malaria in children in an area where sulfadoxine-pyrimethamine resistance was common. Treated children were more likely to harbour resistant parasites.

Source: Bulletin of the World Health Organization

DOI: 10.2471/blt.25.294889

Authors: Beatrice Rotich, Emmah Kimachas, Joseph Kipkoech, Erastus Kirwa, Christine Markwalter, David Ekai, Ann Mwangi, Suzanne Van Hulle, Diana Menya, Wendy Prudhomme O’Meara

Institutions: AMPATH, Duke Institute for Health Innovation, Moi University, Catholic Relief Services

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7215774792

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