From Virtual Patients to Digital Twins in Orthodontics: 4D Simulation Technologies for Diagnosis, Treatment Planning, and Monitoring—A Scoping Review
Year: 2026
Type: study-registration
Abstract: This OSF registration contains the methodological protocol and supplementary files for a scoping review on virtual patients, digital twins, and 4D simulation technologies in orthodontics. The objective of this review is to map the available evidence on the technological components, data sources, clinical applications, validation methods, reported outcomes, and research gaps related to virtual-patient construction, digital-twin modelling, 4D simulation, biomechanical simulation, artificial intelligence-assisted planning, treatment monitoring, and outcome prediction in orthodontics. The review follows the Joanna Briggs Institute methodology for scoping reviews and is reported according to the PRISMA extension for Scoping Reviews. Searches were conducted in Scopus, Web of Science Core Collection, PubMed/MEDLINE, LILACS/BVS, and ClinicalTrials.gov, with no language restrictions and a search period from January 1, 2010, to the final search date. This registration includes the protocol framework, PCC eligibility criteria, complete database-specific search strategies, and full-text screening decisions. The manuscript draft is not included because it is under preparation for journal submission.
Source: Open Science Framework
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7216130355