Preparation and evaluation of polyherbal ethosomal gel using Cassia auriculata, Tecoma stans, and Myristica fragrans
Year: 2026
Type: article
Abstract: Cassia auriculata, Tecoma stans, and Myristica fragrans have been traditionally used in the skin health, particularly to reduce the excessive melanin, to treat dark skin patches and to enhance the skin tone. The present study was undertaken to prepare and evaluate the ethosomes using these herbs and incorporate them into gel to formulate the polyherbal gel. 80% alcoholic extracts of flowers of Cassia auriculata, Tecoma stans, and seeds of Myristica fragrans were subjected to phytochemical and physicochemical analysis. Subsequently the extracts were combined in the equal proportions to form ethosomes and characterized. The polyherbal gel was prepared incorporating the ethosomal solution of the extract into gel base. The gel was evaluated for various physicochemical parameters. The formulated gel exhibited satisfactory physical characteristics, good consistency, and stability throughout the evaluation period. The presence of phenolic and flavonoid compounds may contribute to antioxidant and skin-protective effects, thereby helping in the management of hyperpigmentation. The findings suggest that the developed polyherbal gel possesses desirable properties for topical application and may serve as a promising herbal alternative for the treatment of hyperpigmentation.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7216295083