Antidiabetic potentiality of aqueous leaf extract of Leucas zeylanica in alloxan-induced diabetic rats
Year: 2016
Type: article
Abstract: The study was designed to evaluate the blood glucose lowering effect of the aqueous extract of Leucas zeylanica leaf using the alloxan-induced diabetic rats and compared the activity with diabetic control and antidiabetic drug (Glibenclamide). Leaf extract (50 mg/kg) of Leucas zeylanica and Glibenclamide were administered to normal and experimental diabetic rats for the duration of 10 days. In the alloxan-induced diabetic rat model, Leucas zeylanica extract (50 mg/kg) significantly (P < 0.05) lowered the fasting blood glucose level. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight and liver glycogen levels assessed in the extract treated to the diabetic rats were compared with diabetic control and normal rats. Significant results (P < 0.05) were observed in the estimated parameters. Surprisingly, body weight was increased significantly (P < 0.05) in Leucas zeylanica treated diabetic group.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: University of Chittagong
OpenAlex ID: W7216625994