Effect of Isoflurane and Sevoflurane on Women Undergoing Cesarean Section: Anesthesia in CS
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: The anesthetic drugs should be used with caution since a lot of them were with side effect induction. Aim: To investigate the comparative effects of two commonly used volatile anesthetic agents, isoflurane and sevoflurane, on women undergoing cesarean section under general anesthesia. Methods: A hospital-based descriptive cross-sectional observational study was conducted in two general hospitals in Kirkuk. A total of 172 women attend for cesarean section were included in the study. Informed consent was taken from each woman before her enrollment in the study. The data was gathered using a structured questionnaire. The data analyzed using IBM SPSS (version 25). A p-value of <0.05 is regarded as significant. Results: A rate of 68.6% of the participants experienced psychological effects following anesthesia. While 61.3% of the participants experienced sleeping difficulty. In addition, 72.1% developed breathing difficulty after surgery. The rate of pain severity was that 51.7% of the participants were with moderate pain, while 30.2% experienced severe pain. 56.4% of the participants do not get information or get an inadequate explanation regarding anesthesia side effects. Unfortunately, 59.3% of the participants experienced not good team cooperation or no cooperation at all. Isoflurane used in 89%, while sevoflurane used in 11% of women undergoing CS. The wake-up time after surgery was 20–40 minutes in 79.7%, while it was 41–50 minutes in 20.3%. There were significant differences between isoflurane and sevoflurane perioperative levels of glucose, systolic blood pressure, and diastolic blood pressure. However, there was no significant difference between the two drugs use in regard to blood loss. In addition, there were significant differences between the two drugs when the analysis was performed on diabetic or hypertensive and non-diabetic or non-hypertensive strata. Conclusion: Isoflurane had more effect on systolic and diastolic blood pressure than sevoflurane during surgery. Additionally, after surgery there was a significant difference in systolic and diastolic blood pressure between women who received isoflurane and those who received sevoflurane. Both drugs induce significant reduction in systolic blood pressure, while there was no significant effect on diastolic blood pressure and blood glucose levels after their use.
Institution: Al-Qalam University
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7217049005