Year: 2018
Type: article
Study design: Observational Study
Abstract: Summary. Objective: to study arginase activity/expression in the peripheral blood cells of patients with the different forms of leukemia. Object and methods: arginaseactivity was measured in the peripheral blood lymphocytic fraction of patients with B-cell chronic lymphoid leukemia (71 patient); different kinds (M1–M5) of acutemyeloid leukemia (53 patients); B-cell acute lymphoidleukemia (8 patients); different forms of non-Hodgkin’slymphoma (30 patients) and 10 donors. Also, there wasmeasured Arg I protein expression in the cellular extractsof the same blood fraction. Results: arginase activity of theB-cell chronic lymphoid leukemia patients’ lymphocyteswas found to be significantly highest between all patientsbeen studied. The lowest arginase activity was found inthe lymphocytic fraction of the B-cell acute lymphoid leukemia patients. Conclusion: measurement of the arginaseactivity/expression in the peripheral blood lymphocytic fraction may be proposed as a supplement criterion tospecify diagnosis of some forms of leukemia.
Source: Oncology
Language: Ukrainian
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7217528895