ปัจจัยที่ส่งผลต่อการเสียชีวิตของผู้ป่วยติดเชื้อในกระแสเลือดที่เกิดจากเชื้อแบคทีเรีย วงศ์ Enterobacterales ที่ดื้อต่อยา ceftriaxone ณ โรงพยาบาลชลบุรี
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To determine factors affecting mortality of patients with bloodstream infection caused by Ceftriaxone-resistant (CRO-R) Enterobacterales at Chonburi Hospital. Methods: A retrospective cohort study was conducted by collecting relevant information from medical records. Eligible patients were adults aged ≥ 18 years with bloodstream infection caused by CRO-R Enterobacterales and hospitalized at Chonburi Hospital from April 1, 2023 to March 30, 2024. The study employed binary logistic regression to determine factors affecting mortality. Results: There were 86 participants. The majority were female (n=38 or 57.58%), Mean age was 62.48 ± 15.16 years. Three most common sources of bloodstream infection were urinary tract infection, primary bacteremia with unknown source and gastrointestinal and intra-abdominal infection. Multivariate analysis revealed that two factors having significant association with mortality of patients with bloodstream infection caused by (CRO-R) Enterobacterales were primary bacteremia (aRR 11.88, 95%CI: 1.25, 113.13, P = 0.031) and septic shock (aRR 51.91, 95%CI: 4.19, 643.03, P = 0.002). Conclusion: Primary bacteremia and septic shock were factors affecting mortality of bloodstream infection patients caused by CRO-R Enterobacterales. However, the limitations of this study include small sample size and study setting focused only on internal medicine ward. Therefore, further studies should explore additional factors to enhance the accuracy of mortality predictions.
Language: Thai
Subfield: Microbiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7217850486