คุณสมบัติทางชีวภาพของปูนพอต์แลนด์ซีเมนต์ขาวและผลกระทบของนาโนซิลิกาต่อความแข็งแรงของปูนพอต์แลนด์ซีเมนต์ขาวเพื่อการนำไปใช้เป็นวัสดุทดแทนกระดูก
Year: 2026
Type: article
Abstract: White Portland Cement (WPC) is a ceramic material primarily composed of tricalcium silicate and dicalcium silicate, with a ferric oxide content of less than 0.5%. This composition makes it suitable for medical applications, particularly in orthopedic and dental surgery. This study focuses on developing composite material by incorporating nano-silica into WPC to enhance its mechanical and biological properties. The primary objective is to evaluate the biocompatibility and mechanical performance of the material through in vitro testing, including immersion in simulated body fluid (SBF) and cytotoxicity assessment on osteoblast cells. The results indicate that WPC exhibits both osteoinductive and osteoconductive properties, as evidenced by hydroxyapatite formation on its surface after 28 days of immersion in SBF. Cytotoxicity testing revealed that higher material concentrations reduced cell viability due to the release of calcium hydroxide (Ca(OH)₂), which may increase alkalinity beyond biocompatible levels. Regarding mechanical properties, the addition of nano-silica at 1%, 2%, and 3% significantly enhanced the material’s compressive strength. The highest compressive strength, 58.12 MPa, was observed at a 3% nano-silica concentration, attributed to structural reinforcement, reduced porosity, and increased formation of calcium silicate hydrate (C-S-H) gel, a key component in improving mechanical strength. These findings demonstrate that the development of a WPC-nano-silica composite enhances both mechanical and biological properties, highlighting its potential as a bone substitute material for medical applications.
Institutions: Khon Kaen University, Chaiyaphum Rajabhat University
Language: Thai
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W7218170053