Correlation of Albumin Levels and Systemic Immune Inflammation Index (SII) In Breast Cancer Patiens Undergoing Chemotherapy
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Breast cancer is a major public health issue, especially for women. Breast cancer occurs when abnormal breast cells grow uncontrollably, forming tumors that can spread to other parts of the body. Chemotherapy, as one of the main treatments. Chemotherapy aims to cure cancer by stopping its progression, shrinking tumors, reducing symptoms and complaints, and preventing complication. However, chemotherapy is known to trigger inflammation that affects albumin levels and the Systemic Immune-Inflammation Index (SII). Low albumin levels and increased SII are associated with poor prognosis in cancer patients Method: This study used a descriptive analytical design with a cross-sectional approach. The sample consisted of 85 breast cancer patients at Arafah Islamic Hospital in Jambi City who underwent chemotherapy and had complete hematology data. The data were analyzed using Spearman's correlation test. Result: The average albumin level of patients was 3.08 g/dL, below the normal value. The average SII value was 764.39. The correlation test results showed a significant relationship between albumin levels and SII (p=0.025). Conclusion: There is a significant relationship between albumin levels and SII in breast cancer patients undergoing chemotherapy. Decreased albumin and increased SII can be used as biomarkers in monitoring patient prognosis.
Institution: Poltekkes Kemenkes Jambi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7218923975