Ameloblastic Carcinoma with Unusual Anterior Mandibular and Pharyngeal Extension in a Patient with Metachronous Renal Cell Carcinoma: A Case Report of a Complex Diagnostic Challenge
Year: 2026
Type: article
Study design: Case Report
Abstract: Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor characterized by aggressive local behavior and the potential for regional and distant metastasis.Anterior mandibular involvement with pharyngeal extension is exceptionally rare and poses significant diagnostic challenges.We report a 74-year-old man who presented with dysarthria, restricted tongue mobility, submental swelling, and intermittent intraoral bleeding.Imaging revealed an ill-defined radiolucent lesion in the anterior mandible with cortical destruction and extension into the oropharyngeal region.Incisional biopsy confirmed AC.Metastatic workup demonstrated bilateral cervical lymphadenopathy and multiple pulmonary nodules.A history of renal cell carcinoma (RCC), created diagnostic uncertainty regarding the origin of the distant lesions.The lesion was staged as T4bN2cM1 and deemed surgically unresectable.Palliative management was initiated; however, the patient died shortly thereafter.This case highlights a rare co-occurrence of atypical anatomical presentation and multi-malignancy diagnostic complexity, emphasizing the need for refined diagnostic strategies in similar scenarios.
Source: Jordan journal of dentistry.
DOI: 10.14525/jjd.88
Institutions: University of Jordan, Al-Balqa Applied University
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7219635386