Synergy of umbilical cord-derived exosomes and fractional CO2 laser in hand rejuvenation: structural characterization using ultra-high-frequency ultrasound and color doppler
Year: 2026
Type: article
Study design: Clinical Trial
Abstract: Background: One of the areas of the body most exposed to environmental factors, yet often overlooked, is the hands. This vulnerability, coupled with their functional and expressive importance, has driven the development of new rejuvenation strategies for this region. Objective: To evaluate the efficacy of umbilical cord-derived exosomes delivered using the CO₂ fractional laser-assisted drug delivery technique for hand rejuvenation. Methods: A quasi-experimental study was conducted, involving 15 patients who met the selection criteria. Photographic documentation, ultrasound evaluation, and analysis of skin texture, spots, and pores were performed using a skin analyzer. After skin preparation, a fractional CO₂ laser was applied to both hands. Reconstituted lyophilized exosomes were administered to the right hand, and a placebo solution was applied to the left. Results: The participants’ mean age was 51.2 ± 8.9 years. At 30 days, photographic documentation and instrumental analysis reported improvements in texture, wrinkles, spots, and pores. Similarly, ultrasound revealed an increase in dermal thickness in both hands. A significant reduction in SLEB thickness (p < 0.05) was observed only in the hand treated with exosomes. Conclusions: Increased dermal thickness and reduced SLEB were associated with an overall improvement in skin quality. These preliminary findings suggest that umbilical cord-derived exosomes delivered via fractional CO2 laser-assisted drug delivery may represent a promising adjunctive approach for hand rejuvenation. Larger controlled studies with a longer follow-up are warranted.
Source: Aesthetic Medicine
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7219643328