กรณีศึกษา : การศึกษาความรุนแรงและคุณสมบัติของเชื้อไวรัสปากและเท้าเปื่อย ซีโรไทป์ O สายพันธุ์ O/ME-SA/Ind-2001e ที่แยกได้จากการระบาดในจังหวัดประจวบคืรีขันธ์และจังหวัดสระบุรี ปี 2565
Year: 2025
Type: article
Abstract: This study aimed to investigate the characteristics of the foot-and-mouth disease virus (FMDV) belonging to the O/ME-SA/Ind-2001e lineage, which was isolated from outbreaks in Prachuap Khiri Khan and Saraburi provinces in 2022.The findings were intended to serve as a reference for monitoring potential future changes in viral properties.Four virus isolates were confirmed as FMDV serotype O using the ELISA serotyping method.Molecular analysis identified all four isolates as belonging to the O/ME-SA/Ind-2001e lineage, with nucleotide sequence similarities of 97.00 -98.10 % to the RRL reference FMDV strain.Vaccine matching test demonstrated that the serotype O vaccine strain produced by the government showed a good match with the field isolates, suggesting that the current vaccine is likely effective in preventing the field virus in these outbreaks.Furthermore, preliminary findings indicated that the virus samples obtained from deceased adult dairy cattle during the 2022 outbreaks in Prachuap Khiri Khan and Saraburi provinces may represent a virulent strain of FMDV.These results provide fundamental insights into the viral properties of the outbreak strain.Further studies focusing on the genetic determinants of virulence are recommended to enhance understanding of highly virulent strains and to support the development of effective prevention and control strategies.
Language: Thai
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7219952450