การตรวจสอบคะแนน HoLISTIC ในผู้ป่วยผู้ใหญ่ที่เป็นมะเร็งต่อมน้ำเหลือง ชนิดฮอดจ์กิน แบบคลาสสิก การศึกษาย้อนหลังนำร่องในโรงพยาบาลระดับตติยภูมิ
Year: 2023
Type: article
Study design: Observational Study
Abstract: Adult Hodgkin lymphoma is a treatable hematologic malignancy. The prognostic factors showed differences between developing and developed countries. Seventy-four adult patients, with median age of 29.5 years were enrolled. Totally, 32 patients (43.2%) were stage II, 58.1% presented intermediate risk of IPS-3 and 60.8% showed low risk of IPS-7. Reclassified analysis according to IPS-3, -7 and HoLISTIC (HoLS) showed significantly correlated IPS-3 and IPS-7 (P = 0.001), IPS-3 and HoLS score (p <0.001) and IPS-7 and HoLISTIC score (p< 0.001). Patients presenting 2 HoLS scores had a 5-year overall survival (OS) of 71.8% (p = 0.018) and a 5-year progression-free survival (PFS) of 42.1% (p = 0.025). Preexisting B symptoms and anemia were significant lowerfor both 5-year OS (p = 0.019, 0.034, respectively) and PFS (p < 0.001, 0.001, respectively). Advanced stage and hypoalbuminemia were significant lower only in 5-year PFS (p < 0.001, = 0.03, respectively). HoLS score might be used among Thai adult patients with Hodgkin lymphoma as other international prognostic factors.
Institutions: Rajavithi Hospital, Rangsit University, Mahidol University
Language: Thai
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7220174091