การสอบสวนผู้ป่วยโรคติดเชื้อไวรัสซิกาที่มีอาการแขนและขาอ่อนแรง ในอําเภอหล่มสัก จังหวัดเพชรบูรณ์ ประเทศไทย ปี พ.ศ. 2559
Year: 2024
Type: article
Study design: Case Report
Abstract: Backgrounds: One suspected ZIKV patient with GBS was reported in Lomsak district, Phetchabun province that had prolong ZIKV outbreak in previous three months. Methods: During investigation, we obtain patient’s clinical data from medical records and relatives. The district level ZIKV surveillance system coverage was assessed by comparing number of reported cases with number of medical records meeting surveillance case definition. We interviewed related staff and some villagers about control measure implementation and assessed larva control in houses of recent confirmed cases or patients under investigation of ZIKV and in Lomsak hospital. Results: The case was a 52-year-old Thai female presented with rash and arthralgia for six days, followed by progressive muscle weakness one day later. Zika associated GBS was diagnosed by high protein and low cell count in CSF and positive urine PCR for ZIKV. Intravenous immunoglobulin was administered immediately after having CSF profile and 2 days later she got endotracheal tube intubation due to progressive muscle weakness which then resulted in respiratory failure. She had hospital acquired pneumonia and muscle atrophy during hospitalization. The patient was discharged and fully recovered in 3 months later. ZIKV surveillance system coverage was 61.22%. Assessment of control measures found several problems including inadequate skill of larva control of local staff and the fatigue of control system due to prolong outbreak situation. Conclusion and Recommendations: This patient was the first reported case of zika associated GBS in Asia. Improved surveillance coverage and proactive measures are needed to control ZIKV infection in this area.
Institutions: Ministry of Public Health, Ministry of Public Health
Language: Thai
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7220182086