Cissus quadrangularis Linn.: An Ethnomedicinal Plant with Multisystem Therapeutic Potential and Global Relevance
Year: 2025
Type: article
Abstract: Cissus quadrangularis Linn., commonly known as Hadjod or Asthisamharaka, is a perennial succulent extensively used in traditional Indian medicine and increasingly validated by modern scientific research. This review synthesizes ethnomedicinal knowledge and contemporary pharmacological evidence to highlight the plant’s multisystem therapeutic potential. Rich in bioactive constituents such as flavonoids, triterpenoids, ß-sitosterol, ketosteroids, and vitamins, Cissus quadrangularis demonstrates significant bone-healing, antiinflammatory, analgesic, antioxidant, anti-ulcer, antidiabetic, antimicrobial, and neuroprotective activities. Experimental studies indicate its efficacy in accelerating fracture healing, alleviating osteoarthritic pain, protecting gastric mucosa, regulating blood glucose, and modulating oxidative stress. Emerging evidence also supports its role in neurological disorders due to its ability to cross the blood–brain barrier. Beyond its therapeutic relevance, the plant has gained global importance through its incorporation into functional foods, dietary supplements, and herbal formulations, supported by initiatives from India’s Ministry of AYUSH and international market demand. However, challenges related to standardization, quality control, and clinical validation persist. Integrating traditional knowledge with advanced tools such as metabolomics, green chemistry, and biotechnology may enable sustainable utilization and broader clinical translation of this promising medicinal plant.
Institution: The Assam Royal Global University
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7220337199