Work

PB3711 Rheopheresis increases thrombolytic potential through the generation of fibrinolytic neutrophil-derived extracellular vesicles

Year: 2026

Type: conference-abstract

Abstract: Critical limb ischemia in hemodialysis patients is characterized by microvascular dysfunction that can be improved by rheopheresis, an extracorporeal apheresis technique based on double blood filtration. Although rheopheresis has been shown to enhance tissue perfusion, partly through the removal of high–molecular-weight proteins and anti-inflammatory effects, the mechanisms underpinning its therapeutic benefit remain poorly understood. Because apheresis membranes may trigger cellular activation and the release of extracellular vesicles (EVs) that modulate hemostasis, we hypothesized that rheopheresis promotes EV generation and alters their procoagulant and fibrinolytic activities.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.106330

Authors: Analucia Conca, Akhil Konkoth, Evelyne Abdili, Justine Solignac, Arnaud Laurent, Sylvie COINTE, Sandra Ghayad, Corinne Chareyre, Amandine Bonifay, Burtey Stephane, Philippe Brunet, Françoise Dignat-George, Thomas Robert, Romaric Lacroix

Institutions: Hôpital de la Timone, Hôpital de la Conception, Hôpital Saint Joseph

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250

OpenAlex ID: W7220378283

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