Work

PB2735 Direct Oral Anticoagulants versus Vitamin K Antagonists for the Treatment of Venous Thromboembolism in Sickle Cell Disease: A Bayesian Meta-Analysis

Year: 2026

Type: conference-abstract

Abstract: Direct Oral Anticoagulants (DOACs) are increasingly used as alternatives to Vitamin K Antagonists (VKAs) for the treatment of venous thromboembolism (VTE) in patients with sickle cell disease (SCD). However, comparative evidence on their efficacy and safety in this population remains limited to small observational studies. Previous frequentist meta-analyses may lack robustness given small sample sizes and zero-event data in some studies.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.105474

Authors: Sylvain Le Jeune, Isabelle Mahé, Antonio Morabito, Jérémy Datchanamourty, Florent Happe, Edouard Versini, Louis Affo, Corinne Frere

Institution: Assistance Publique – Hôpitaux de Paris

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250

OpenAlex ID: W7220397359

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