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PB2344 Thrombosis and adverse events associated with Asparaginase in the Treatment of Acute Lymphoblastic Leukemia: Toxicity Profile

Year: 2026

Type: conference-abstract

Abstract: Asparaginase is a fundamental component of multi-agent chemotherapy-regimens for acute lymphoblastic leukemia(ALL). Despite its efficacy in improving survival rates, its clinical utility is often challenged by a spectrum of toxicities (hypersensitivity reactions, hepatotoxicity, pancreatitis and coagulopathies) resulting from systemic protein synthesis inhibition, such as fibrinogen and antithrombin, creating a hemostatic scenery that increases the risk of venous thromboembolism (VTE), particularly during induction.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.105084

Authors: María de la Paz Domínguez, Sergio Gómez, Gina Gutiérrez García, Alejandra Deana, Flavia Pérez Ventura, Eduardo Rodríguez Boughier, Estefanía Tarsetti, Federico Filardi, Cecilia Garbini

Institution: Hospital Posadas

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250

OpenAlex ID: W7220439165

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