Work

PB2681 Systemic Fibrinolytic Dysregulation, Altered extracellular vesicles and Thrombo-Inflammatory Signatures Across Pulmonary Embolism and Lung Cancer

Year: 2026

Type: conference-abstract

Abstract: Dysregulated fibrinolysis is central to thromboembolic disease and cancer-associated complications, yet its systemic functional and molecular characteristics remain incompletely defined. Pulmonary embolism (PE) is associated with profound thrombo-inflammatory activation, while lung cancer (LC) patients undergoing resection frequently develop complications such as prolonged air leaks (PAL), potentially driven by altered fibrin turnover. Interestingly, extracellular vesicles (EVs) have emerged as circulating mediators that reflect cellular stress and coagulation status.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.105420

Authors: Prakasha Kempaiah, Mira Nigudkar, Anuha Vellanki, Alexander Pohlman, Fakiha Siddiqui, Chongyu Zhang, Walter Jeske, Debra Hoppensteadt, Jeanine Walenga, Jean Amiral, Grigoris Gerotziafas, Amir Darki, Zaid Abdelsattar, W. Keith Jones, Jawed Fareed

Institutions: Loyola University Chicago, Inserm, Sorbonne Université

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250

OpenAlex ID: W7220459682

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