Work

OC 76.5 mRNA and Self-Amplifying mRNA-Encoded scFv Targeting Activated GPIIb/IIIa for Safer Thromboprophylaxis

Year: 2026

Type: article

Abstract: Thrombosis is a leading cause of morbidity and mortality in cardiovascular disease. Although current antiplatelet therapies reduce thrombotic events, their systemic inhibition of platelet function is associated with an increased risk of bleeding. We previously developed a conformation-specific single-chain antibody fragment (scFvαIIbβ3) that selectively targets the activated platelet integrin GPIIb/IIIa, enabling inhibition of pathological thrombosis while preserving physiological haemostasis.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.103843

Authors: Yuyang Song, Hung Nguyen, Pengkai Shi, Ahmed Refaat, Karlheinz Peter, Xiaowei Wang

Institution: Baker Heart and Diabetes Institute

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250