Study on Polymer Variations in Film-based Transdermal Patch Formulations and Their Effect on Physical Characteristics
Year: 2026
Type: article
Abstract: Polymers are essential components in pharmaceutical formulations, particularly as film-forming agents that significantly influence the physical characteristics of dosage forms. Variations in polymer type and concentration can affect the physical properties of pharmaceutical films, including thickness, mechanical strength, elasticity, transparency, folding endurance, disintegration time, and storage stability. This literature review aims to evaluate the potential of polymer variations as film-forming agents on the physical properties of pharmaceutical dosage forms. This literature review aims to evaluate the potential of various polymers as film-forming agents on the physical properties of pharmaceutical preparations. The research method was conducted through a literature review of scientific articles obtained from the PubMed, ScienceDirect, Google Scholar, SpringerLink, and MDPI databases using a combination of keywords related to film-forming polymers and physical properties. A total of 15 articles that met the inclusion criteria from 2020–2026 were descriptively analyzed from various relevant scientific articles on the use of natural, semi-synthetic, and synthetic polymers in pharmaceutical film-based formulations. The results showed that variations in polymer concentration affected film thickness, tensile strength, elongation, folding capacity, and disintegration time. HPMC and PVA were the most widely used polymers and demonstrated the best performance in producing films with good mechanical strength, flexibility, and stability. Therefore, the selection and variation of polymers as film-forming agents are important factors that need to be considered to obtain pharmaceutical preparations with good physical quality, stability, and suitability for therapeutic purposes.
Institution: Universitas Ahmad Dahlan
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7220533045