Year: 2025
Type: article
Abstract: Aim to investigate the effect of vinegar processed Cyperus rotundus on enhancing the efficacy of drugs in the liver, this study used network pharmacology methods to explore the mechanism of vinegar processed Cyperus rotundus on improving non-alcoholic fatty liver disease (NAFLD). The author has compiled relevant literature from both domestic and international sources over the past 10 years, and based on the TCMSP database, identified 16 active ingredients and 471 related targets in vinegar processed Cyperus rotundus. Obtain 1,941 target genes for NAFLD using GeneCards, OMIM, and Drug Bank databases, among them, there are 104 common targets for drugs and diseases. Construct a "drug-ingredient-gene target" network and a PPI network using Cytoscape 3.10.0 software. Obtaining honeysuckle alcohol, isorhamnetin, kaempferol, and other active ingredients as the main active ingredients in the production of vinegar processed Cyperus rotundus in NAFLD. Importing potential targets into the String database for protein interaction analysis, constructing a protein-protein interaction (PPI) network, and identifying AKT1, JUN, IL6, IL1B, and other key target genes through analysis. Perform GO functional enrichment analysis and KEGG pathway analysis on the target of action, The enrichment results showed that vinegar processed Cyperus rotundus improved NAFLD and was associated with multiple liver related metabolic pathways, including TNF signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, and Toll-like receptor signaling pathway. The study shows that vinegar processed Cyperus rotundus may act on core targets such as AKT1, JUN, IL6, and IL1B through active ingredients such as honeysuckle alcohol, isorhamnetin and kaempferol, regulating signaling pathways such as TNF, MAPK, PI3K-Akt signaling to improve NAFLD.
Authors: Yuehan, Liu, Ying, Qing, Wan, Liao, Tianhui, Gao
Language: Chinese
Subfield: Drug Discovery
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7220537924