Impact of Metformin Versus Insulin on Diabetic Pregnancy Outcome, Aljalaa Maternity Hospital
Year: 2025
Type: article
Study design: Observational Study
Abstract: In recent years, metformin has gained acceptance as a safe, effective and rational option for reducing insulin resistance in pregnant women with type 2 diabetes, gestational diabetes (GDM). The study aimed to compare the efficacy and safety of Metformin versus insulin in the treatment of gestational diabetes mellitus (GDM) by evaluating the influence of medication on maternal and fetal outcomes. A retrospective study included 550 diabetic women who were under antenatal follow up in diabetic pregnancy outpatient department and who gave birth in the period from 1st Jan. 2012 up to 31st Dec. 2014 in Aljalaa Maternity Hospital, Tripoli-Libya. The percentage of patients who had normal vaginal delivery was higher in Metformin group (35.6%) compared with insulin group (17.5%) the relationship was significant (P < 0.05), HbA1c% level was < 7% in 35.1% of insulin patients and 66.5% in metformin patients group. About 45% of patients on metformin need supplemental insulin in different stages of pregnancy to fulfill perfect blood sugar control. In this study there was no difference in neonatal outcomes between insulin and metformin patients groups, and there were no statistically significant differences in birth weight between insulin treated patients and metformin treated patient (P =0.5). Metformin was efficacious in controlling diabetes in pregnancy, associated with decreased chance of caesarean delivery and not associated with increased perinatal complications.
Source: Tripolitana Medical Journal
Institution: University of Tripoli
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7220584530