Association of conventional and emerging adiposity indices with albuminuria in Indian type 2 diabetic adults
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Central adiposity may contribute more strongly to renal injury than overall obesity in type 2 diabetes mellitus (T2DM), particularly in South Asian populations characterized by higher visceral fat at lower body mass index (BMI). Objective: To evaluate six adiposity indices-BMI, weight-adjusted waist index (WWI), body adiposity index (BAI), waist-to-height ratio (WHtR), a body shape index (ABSI), and body roundness index (BRI)-and identify the superior predictor of albuminuria in Indian adults with T2DM. Methods: In this hospital-based cross-sectional study, 364 adults with T2DM were enrolled consecutively. Albuminuria (normo-, micro-, or macroalbuminuria) was determined using the urinary albumin-to-creatinine ratio. Group differences were assessed using Welch's ANOVA or Kruskal-Wallis tests. Associations were examined using Spearman's correlation and binary and multinomial logistic regression adjusted for age, systolic blood pressure, HbA1c, smoking, and serum creatinine. Results: = 0.009). In adjusted models, WWI (OR = 1.32; 95% CI = 1.01-1.73) and ABSI (OR = 1.04 per 0.001-unit; 95% CI = 1.01-1.07) were independently associated with albuminuria, unlike BMI and BAI. The ABSI model showed the highest discrimination (AUC = 0.775). Stage-specific analysis demonstrated associations for WWI with macroalbuminuria (OR = 1.66; 95% CI: 1.09-2.53) and for ABSI with microalbuminuria (OR = 1.04; 95% CI: 1.00-1.07) and macroalbuminuria (OR = 1.07; 95% CI: 1.02-1.12). Conclusion: Central adiposity indices WWI and ABSI show modest, independent, and graded associations with albuminuria severity in Indian adults with T2DM.
Institution: All India Institute of Medical Sciences, Rajkot
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $450
OpenAlex ID: W7220833573