Comparative Evaluation of Erythritol and Glycine in Piezo-assisted Guided Biofilm Therapy: A Randomized Controlled Clinical Trial
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objectives: To compare and evaluate the efficacy of erythritol and glycine by piezo-assisted guided biofilm therapy. Materials and Methods: A total of 30 eligible patients were recruited for the study. The study participants were randomly assigned to either Group A (Erythritol group) or Group B (Glycine group) to ensure an unbiased distribution between the two treatment groups. At baseline, for all participants, comprehensive periodontal screening was performed, and plaque index, gingival index (GI) were assessed. After initial screening, disclosing agent (ALPHA PLAC) was applied before treatment for targeted biofilm removal. Group A was treated with an AIRFLOW® device using erythritol powder, and Group B with glycine powder, according to the manufacturer’s protocol. Both supragingival and subgingival polishing were performed by a single calibrated operator. Participants received reinforcement of oral hygiene instructions at each visit. Clinical parameters were reassessed at 1 month and 3 months to evaluate the effectiveness of both powders in nonsurgical periodontal therapy. Results: All the participants were evaluated and examined at baseline and 1 month and 3 months, On statistical evaluation both groups showed significant reduction in Plaque score from 2.21 ± 0.402 to 1.09 ± 0.242 in Erythritol Group and from 2.21 ± 0.348–1.38 ± 0.243 in glycine group and GI Score reduced from 1.81 ± 0.348–0.9 ± 0.283 in erythritol group and in glycine group it showed significant reduction from 1.90 ± 0.359 at baseline to 1.23 ± 0.379 at the end of 3 months. Both groups have shown a significant difference; however, greater improvement was noted in the erythritol group compared with glycine. Conclusion: Piezo-assisted biofilm removal with erythritol is more effective than glycine in enhancing clinical periodontal outcomes.
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7220848486