Work

EARTH-HCM: A Real-World Tool to Visualize the Burden of Hypertrophic Cardiomyopathy in the United States

Year: 2026

Type: article

Abstract: BACKGROUND: There is limited evidence on geographical distribution of hypertrophic cardiomyopathy (HCM) disease burden and a lack of visualization of national data for patient outcomes among patients with HCM. OBJECTIVES: To evaluate the feasibility of leveraging claims data to identify patients with HCM, estimate geographic disease burden, and integrate clinical and economic outcomes within a scalable visualization framework capable of supporting hypothesis generation and future outcomes research. METHODS: EARTH-HCM will be an open access, education tool to visualize patient characteristics, treatments, clinical outcomes, healthcare resource utilization, and costs for patients with HCM. This is a retrospective, observational study of longitudinal claims data from 2016 to 2023, with the first HCM diagnosis being considered the index date. RESULTS: Among 431,457 patients with a diagnosis for HCM, 166,081 (38.5%) patients had oHCM and 265,376 (61.5%) had nHCM. Among HCM patients, 51.1% were male with a mean age of 60.1 (17.7) years and median follow-up of 3.0 (2.4) years. Most patients were in age groups of 65+ (53.4%) and 55-64 (20.5%) and resided in the South (36.3%), followed by the Northeast (24.8%), Midwest (24.3%), and West (14.6%). CONCLUSIONS: EARTH-HCM demonstrates the feasibility of a national real-world surveillance framework to visualize the geographic distribution and healthcare burden of HCM and support future clinical and economic outcomes research.

Source: ESC Heart Failure

DOI: 10.1093/eschf/xvag254