Continuous Glucose Monitoring–Guided Insulin Optimization in Patients Receiving Nocturnal Parenteral Nutrition
Year: 2026
Type: other
Abstract: Objective: To evaluate whether a continuous glucose monitoring system (CGMS)–guided insulin optimization can improve glucose control and nutritional status in insulin-treated patients receiving long-term nocturnal parenteral nutrition (PN). Research Design and Methods: In this prospective single-center study, 12 insulin-treated adults with chronic intestinal failure undergoing nocturnal cyclic PN underwent 30-day CGM assessment before and after a diabetologist-led optimization of insulin therapy. Results: Glucose profiles improved after the intervention: less time >250 mg/dL (27% to 17%; −139 ± 113 min/day; p=0.02), more time in range (44% to 59%; +206 ± 118 min/day; p=0.002), without more hypoglycemia. HbA1c decreased by −0.7% (−8 mmol/mol; p=0.04), and glycosuria resolved in all affected patients (p=0.03). Body weight increased by +5 kg (IQR 4–7.75; p=0.006), as did serum albumin (+8 g/L; p=0.006). Malnutrition resolved among 8/11 participants (p<0.05). Conclusions: CGMS-guided insulin optimization was associated with improvements in glucose control and nutritional status.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7220922641