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Risk Factors for Peripheral Intravenous Infusion–Related Local Adverse Events Associated With Fosaprepitant: A Retrospective Study

Year: 2026

Type: article

Abstract: Objective: Fosaprepitant, an intravenous neurokinin-1 (NK1) receptor antagonist used to prevent chemotherapy-induced nausea and vomiting, is known to cause local adverse events at peripheral infusion sites, including vascular pain and phlebitis. Although female sex and the number of chemotherapy cycles have been reported as risk factors, the association between concomitant antineoplastic agents and local adverse events has not been comprehensively investigated.

Source: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)

DOI: 10.5649/jjphcs.52.679

Authors: Kayo Motomura, Keisuke Kongo, Katsuya Makihara, Tomokazu Matsumura

Institution: Yodogawa Christian Hospital

Language: English

Topic: Nausea and vomiting management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7221121237