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Primary Epstein–Barr virus-negative lymphoepithelioma-like carcinoma of the supraglottic larynx mimicking nasopharyngeal carcinoma: a case report

Year: 2026

Type: article

Abstract: Lymphoepithelioma-like carcinoma (LELC) of the larynx is exceptionally rare and can closely mimic undifferentiated nasopharyngeal carcinoma. A 78-year-old man presented with progressive dysphonia and dysphagia. Endoscopy and computed tomography showed a supraglottic lesion with bilateral cervical lymphadenopathy (cT2N2M0). Biopsy demonstrated poorly differentiated non-keratinizing carcinoma with dense lymphoid stroma and a Schmincke-type pattern. Tumor cells were positive for p40, p63, and pancytokeratins; Epstein-Barr virus testing was negative. After exclusion of a nasopharyngeal primary, the diagnosis of primary laryngeal LELC was established. Definitive cisplatin-based chemoradiotherapy with intensity-modulated radiotherapy (70 Gy in 35 fractions) achieved complete clinical and radiological response at 12 months with preserved swallowing and phonatory function.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjag908

Authors: Fabrizio Crudo, Nicola Di Giuseppe, Franco Brandimarte, Giovanna Granchelli, Pietro Romualdi

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000

OpenAlex ID: W7221566471

FWCI:

Cites: 9

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Related to: 10