Phase 5 — Forensic Research Recovery, Mathematical Reconstruction, and Reproducibility Restoration
Year: 2026
Type: report
Abstract: This research supplement documents the forensic recovery, mathematical reconstruction, and reproducibility audit of Phase 5 of Genomic and Molecular Analysis of a 17p13.3 Microdeletion and Its Candidate Visual-Neurological Mechanisms (Frozen Version 1.0, September 30, 2026). Nine accessible historical and project source files were examined, including a 19-worksheet retrospective aggregate workbook. Nineteen exact descriptive calculations were reconstructed from preserved inputs, and two original simulation specifications were recovered. The original numerical scoring functions, stochastic outputs, random seeds, and complete technical manuscript could not be recovered. A new, independently specified computational analysis executed 32 methodological simulation scenarios comprising 640,000 Monte Carlo replications. These simulations evaluated statistical power, multiple-testing risk, and pseudoreplication. They do not constitute reproductions of the historical simulations or empirical measurements of the index deletion. Forty-four parameter groups remain unresolved or mathematically non-identifiable. The original matched-genomic-null empirical significance remains NOT_ESTIMABLE. The project's distributed functional-reserve hypothesis remains a biologically plausible working interpretation. However, the recovered and newly generated evidence does not establish that the reported heterozygous 17p13.3 deletion causes cortical photosensitivity, photoparoxysmal responses, or visually triggered seizures. This supplement preserves the frozen scientific conclusions while improving computational transparency, provenance documentation, and reproducibility. The research has not undergone external peer review.
Author: Laing, Zachariah
Language: English
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W7222425290