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Characterization of von Willebrand factor-enriched extracellular vesicles and their association with platelet adhesion in COVID-19

Year: 2026

Type: article

Study design: Observational Study

Abstract: Circulating small extracellular vesicles in patients with COVID-19 carrying ultra-large VWF multimers boost platelet adhesion and activate endothelial cells, highlighting a potential driver and biomarker of COVID-19-associated coagulopathy.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00374.2026

Authors: Ling Chen, Aatish Mahajan, Anil Kumar Ram, Prabhakar Chalise, Quan Zhang, Huan Dong, Zhijian Wu, Liang Zheng, X. Long Zheng, Leslie Spikes, Navneet Kaur Dhillon

Institution: University of Kansas Medical Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, American Lung Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences

Awards: Novel Approaches for the Control of Microbial Pathogens, Long-COVID in people living with HIV

OpenAlex ID: W7223664515

FWCI:

Cites: 38

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Related to: 10