Antimicrobial Potency of California Papaya Seed Extract (Carica papaya Linn) in Denture Cleanser Against Streptococcus mutans and Candida albicans - An In Vitro Study
Year: 2026
Type: article
Abstract: BACKGROUND: Tooth loss, a prevalent issue in Indonesia, is usually treated with prostheses such as dentures to restore stomatognathic function. However, dentures may serve as a medium for pathogenic microorganisms such as Streptococcus mutans and Candida albicans to adhere to the teeth and oral mucosa. Streptococcus mutans is linked to dental caries, whereas Candida albicans is commonly linked to denture stomatitis. Plaque and microbial biofilm cleaning are more effective when done chemically by soaking in a denture cleanser. The use of herbal plants for medicine is being widely developed, such as papaya plants. Numerous studies have demonstrated that papaya seeds contain active chemicals with antibacterial and antifungal qualities, including phenols, alkaloids, tannins, saponins and flavonoids. AIM: To evaluate the antimicrobial potential of California papaya seed extract in denture cleanser formulations against Streptococcus mutans and Candida albicans . MATERIALS AND METHODS: A post-test-only control group design was used in this experimental investigation. Dilution tests with five distinct concentrations (48%, 24%, 12%, 6% and 3%) were among the tests conducted with four replications for each group. Kruskal-Wallis and Dunn's post-hoc tests were used to assess differences between groups. RESULTS: California papaya seed extract in denture cleanser formulation was able to suppress the proliferation of Streptococcus mutans , with a minimum inhibitory concentration (MIC) of 12% and a minimum bactericide concentration of 24%. For Candida albicans , the results showed an MIC at a concentration of 24% and a minimum fungicide concentration of 48%. CONCLUSION: California papaya seed extract in denture cleanser formulation has antimicrobial potency against Streptococcus mutans and Candida albicans .
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $150
OpenAlex ID: W7224100997