Work

Loss of akt-1 throughout development leads to abnormal chemosensory behaviors in C. elegans

Year: 2026

Type: article

Abstract: The C. elegans AKT serine/threonine kinase AKT-1 is widely studied because it is a molecular player in multiple ubiquitous signaling pathways.akt-1 mutants have been associated with gross, organismal-level phenotypes.In addition to organismal physiology, pathways associated with akt-1 are known to regulate neuronal plasticity and behavior; therefore, akt-1 mutants could be valuable for behavioral characterization.Here, we report that akt-1 loss-of-function mutants demonstrate perturbed chemotaxis behaviors which could confound experiments that rely on proper chemosensation.We also determined that adult-only administration of akt-1 RNAi is sufficient to overcome these behavioral deficits, suggesting these defects are likely developmental in origin.

Source: microPublication biology

DOI: 10.17912/micropub.biology.002473

Authors: Meredith I Williams, Hope Msengi, Rachel Arey

Institution: Baylor College of Medicine

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: diamond

Funders: National Institutes of Health, NIH Office of the Director

Awards: G6379324417, G748625499, Caenorhabditis Genetics Center