Association of Cholinesterase Inhibitor–Memantine Combination Therapy With Long-Term Community Management and Mortality in Patients With Dementia: A Nationwide Retrospective Cohort Study
Year: 2026
Type: article
Abstract: Background and Purpose: Long-term real-world outcomes of acetylcholinesterase inhibitor (AChEI)-memantine combination therapy remain uncertain. We evaluated treatment patterns and associations of combination therapy with 5-year community management and mortality in patients with dementia. Methods: Using customized Korean National Health Insurance Service data, we identified patients newly diagnosed with dementia from 2003 to 2018. The main analysis included patients who had not received memantine during the first year after diagnosis but initiated it thereafter. Five-year community management and all-cause mortality were compared between memantine monotherapy and AChEI-memantine combination therapy and examined according to combination-therapy duration. Results: for trend <0.001). Conclusions: AChEI-memantine combination therapy was associated with more favorable 5-year outcomes than memantine monotherapy among later memantine initiators. These observational findings require confirmation with analyses addressing clinical severity, treatment selection, and time-related bias.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7224927673