Data from Changes in Alcohol Use among Adults with Cancer Participating in the ECOG-ACRIN EAQ171CD Tobacco Treatment Trial
Year: 2026
Type: other
Abstract: Background: Alcohol and tobacco use are known carcinogens. Treating alcohol and tobacco co-use can improve treatment and survivorship outcomes among patients diagnosed with cancer. Methods: We conducted a post hoc analysis of ECOG-ACRIN EAQ171CD trial participants within the National Cancer Institute (NCI) Community Oncology Research Program (NCORP), examining changes in alcohol use among adults receiving the virtual sustained treatment (VST) for tobacco use intervention versus enhanced usual care (EUC; Quitline referral). Multivariable logistic regression assessed changes in alcohol use disorder (AUD) risk at 3 and 6 months using the Alcohol Use Disorders Identification Test Concise (AUDIT-C). Results: At baseline, participants (N = 305) were classified as having no risk (31%), low/minimal risk (38%), moderate risk (23%), or high risk (8%) for AUD. The mean age was 55.6 years, participants smoked for an average of 33 years, and 18% had alcohol-associated tumors. Participants randomized to EUC were more likely to shift to a lower alcohol risk category than those in the VST arm at 3 months (39% vs. 27%) and 6 months (33% vs. 27%). There was no significant difference in the odds of shifting to a lower risk category for VST versus EUC at 3 months [adjusted odds ratio (OR), 0.56; 95% confidence interval (CI), 0.26–1.18; P = 0.125] or at 6 months (adjusted OR, 0.57; 95% CI, 0.25–1.28; P = 0.172). Conclusions: Patients diagnosed with cancer and engaging in alcohol and tobacco co-use can achieve reductions in alcohol use and risk. Impact: Integrating tailored, co-use–focused strategies into cessation programs may improve changes in modifiable risk behaviors.
Authors: Angela Wangari Walter, JoRean D. Sicks, Alexander Taurone, Sai Priyanka Mellacheruvu, Rachel L. Rosen, Brett M. Goshe, Ilana F. Gareen, Benjamin A. Herman, Autumn W. Rasmussen, Alona Muzikansky, Susan Regan, Douglas E. Levy, Michael A. Thompson, Laura Malloy, Irina Gonzalez, Lucy Finkelstein-Fox, Nathan D. Munson, Molly M. Greenwade, David M. King, Bharat Jenigiri, Brian L. Burnette, Alyssa D. Throckmorton, Martha S. Tingen, Ruth C. Carlos, Lynne I. Wagner, Jamie S. Ostroff, Elyse R. Park
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7225097656