Hubungan derajat anemia dengan respon klinis pengobatan akhir fase intensif bulan 2 pada pasien tuberkulosis sensitif obat
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Drug-susceptible tuberculosis (DS-TB) remains a public health issue in Indonesia. Anemia, which frequently co-occurs in DS-TB patients, is thought to potentially influence the clinical response to treatment by reducing oxygen-carrying capacity and impairing immune function. Purpose: To determine the association between the severity of anemia and the clinical response to treatment at the end of the 2-month intensive phase in patients with drug-susceptible tuberculosis. Method: This was an observational, analytical study with a cross-sectional design, utilizing medical record data from DS-TB patients at Bintang Amin Hospital between January and December 2025. A total of 37 patients who met the inclusion and exclusion criteria were selected using a total sampling technique. Bivariate analysis was performed using Fisher's Exact Test. Results: A total of 23 patients (62.2%) had mild anemia, while 14 patients (37.8%) had moderate anemia. A favorable clinical treatment response was observed in 24 patients (64.9%), whereas an unfavorable clinical response was found in 13 patients (35.1%). Fisher's Exact Test indicated a significant association between the severity of anemia and the clinical treatment response in DS-TB patients (p = 0.001; OR = 16.667; 95% CI: 3.111–89.284). Conclusion: There is a significant association between the severity of anemia and the clinical treatment response at the end of the 2-month intensive phase in patients with drug-susceptible tuberculosis. Patients with mild anemia tend to exhibit a better clinical treatment response compared to those with moderate anemia. Keywords: Anemia Severity; Clinical Treatment Response; Drug-Susceptible Tuberculosis; Hemoglobin. Pendahuluan: Tuberkulosis sensitif obat (TB SO) masih menjadi masalah kesehatan masyarakat di Indonesia. Anemia yang sering menyertai pasien TB SO diduga dapat memengaruhi respon klinis pengobatan melalui penurunan kapasitas transportasi oksigen dan gangguan fungsi imun. Tujuan: Untuk mengetahui hubungan derajat anemia dengan respon klinis pengobatan akhir fase intensif bulan 2 pada pasien tuberkulosis sensitif obat. Metode: Penelitian analitik observasional dengan pendekatan cross-sectional menggunakan data rekam medis pasien TB SO periode Januari–Desember 2025, di Rumah Sakit Bintang Amin. Sampel sebanyak 37 pasien yang memenuhi kriteria inklusi dan eksklusi diambil dengan teknik total sampling. Analisis bivariat dilakukan menggunakan uji Fisher's Exact Test. Hasil: Sebanyak 23 pasien (62.2%) mengalami anemia derajat ringan dan 14 pasien (37.8%) mengalami anemia derajat sedang. Respon klinis pengobatan baik ditemukan pada 24 pasien (64.9%), sedangkan respon klinis tidak baik ditemukan pada 13 pasien (35.1%). Hasil uji Fisher's Exact Test menunjukkan terdapat hubungan yang bermakna antara derajat anemia dengan respon klinis pengobatan pada pasien TB SO (p = 0.001; OR = 16.667; 95% CI: 3.111–89.284). Simpulan: Terdapat hubungan yang bermakna antara derajat anemia dengan respon klinis pengobatan akhir fase intensif bulan 2 pada pasien tuberkulosis sensitif obat. Pasien dengan derajat anemia ringan cenderung memiliki respon klinis pengobatan yang lebih baik dibandingkan pasien dengan derajat anemia sedang. Kata Kunci: Derajat Anemia; Hemoglobin; Respon Klinis Pengobatan; Tuberkulosis Sensitif Obat.
DOI: 10.56922/pti.v6i6.22
Institution: Universitas Malahayati
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7225311307