Work

1990—2023年中国归因于高空腹血糖的肝癌疾病负担研究

Year: 2026

Type: article

Abstract: Objective To analyze the temporal trends in the burden of liver cancer attributable to high fasting plasma glucose (HFPG) in China from 1990 to 2023 so as to provide a scientific basis for developing targeted prevention and control strategies. Methods Population attributable fraction (PAF), mortality, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) attributable to HFPG among patients with liver cancer in China, globally, and across different socio-demographic index (SDI) regions from 1990 to 2023 were extracted from the 2023 Global Burden of Disease Study (GBD) database. Joinpoint regression models were used to analyze the temporal trends and change in ASMR and ASDR attributable to HFPG-related liver cancer. The average annual percentage change (AAPC) was calculated. Results The PAF of liver cancer attributable to HFPG in China increased from 1.91% to 2.43% (AAPC=0.81%, P<0.001), mortality increased from 1,696 to 3,617 (AAPC=2.17%, P<0.001), and DALYs increased from 51,800 to 87,800 person-years (AAPC=1.41%, P<0.001) between 1990 and 2023. Significant sex differences were observed. The gender ratios of liver cancer deaths, ASMR, DALYs, and ASDR attributable to HFPG in China were 1.09∶1, 1.21∶1, 1.28∶1, and 1.37∶1, respectively in 2023. The growth rate of attributable deaths and DALYs in men far exceeded that in women from 1990 to 2023. The attributable mortality rate and DALY rates generally increased with age across all age groups. The highest attributable mortality rate was in the ≥80 age group (1.61/100,000), while the highest attributable DALY rate was in the 75-79 age group (21.33/100,000) in 2023. Compared to 1990, the attributable mortality rate and DALY rate in both the 75-79 and ≥80 age groups were higher in 2023. ASMR and ASDR showed differentiated trends from 1990 to 2023 in China and globally. ASMR and ASDR decreased by an average of 0.84% and 1.36% annually, respectively, in China, while globally, ASMR and ASDR increased by an average of 0.86% and 0.56% annually, respectively. ASMR and ASDR attributable to HFPG showed upward trends in low, low-middle, middle, and high SDI regions (P<0.001), with the fastest rate of increase in the low-middle SDI region (AAPC of ASMR=1.51%, AAPC of ASDR=1.48%). Conclusion The absolute burden of liver cancer attributable to HFPG in China continued to rise from 1990 to 2023. However, the age-standardized rate showed a downward trend in the context of an aging population, suggesting the initial effectiveness of prevention and control measures. Enhanced blood glucose management and liver cancer screening are needed for key populations such as males and the elderly to further reduce the disease burden.

Source: PubMed Central

DOI: 10.3760/cma.j.cn501113-20260130-00050