Life as memory. Memory as life: hysteretic kinetics in the SABIO-RK database
Year: 2026
Type: preprint
Abstract: Reconnaissance of the SABIO-RK kinetic database: 76,780 records, 100% coverage, zero corrupted lines. Three findings. (1) Hill coefficients: 2,826 records, median n = 1.5, 49.4% of values above 1.5 — equilibrium cooperativity is systematic in a static reference database. (2) Memory: 23 records in two publications with "hysteretic" in the title — human DHFR, 1989 (17 records) and rat pyruvate kinase, 1974 (6 records, up to 10 parameters including transition rate constants). The kinetic-law type "hysteretic" is absent from the schema; the term survives only in the bibliography. (3) Lag: zero records — the concept is absent from the lexicon entirely, even in the hysteretic works. Conclusion: measured non-equilibrium dynamics exist in the data, but the schema does not mark them. The hysteresis loop — the only loop that culture draws in full — is proposed as a common signature of two time scales in one carrier: proteins, viruses, humans. The full research log, including the dialogue protocol and illustrations, is published as supplementary material (Proza.ru, publication certificates No. 226110801428, No. 226110801460, No. 226110801495).
Author: Borodin, Oleg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225594591