NEKi-S3 Guideline
Year: 2026
Type: study-registration
Abstract: Neuroimmunological diseases such as multiple sclerosis (MS), myasthenia gravis (MG), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are frequently diagnosed in women of reproductive age, for whom family planning and the desire to have children may be highly relevant. Pregnancy and the postpartum period can raise important clinical questions regarding disease activity, maternal health, pregnancy outcomes, and the safety of immunomodulatory therapies. Similar uncertainties may arise for men with neuroimmunological diseases who wish to father a child. The planned systematic review will systematically identify, critically appraise, and synthesize the available evidence on the relationship between neuroimmunological diseases, immunomodulatory therapies, and reproductive outcomes. Depending on the specific evidence available, relevant outcomes will include disease activity during pregnancy and the postpartum period, maternal health, fertility, pregnancy and neonatal outcomes, congenital malformations, hematological abnormalities, and other relevant maternal, fetal, or neonatal complications. Evidence regarding the management of immunomodulatory treatment before conception, during pregnancy, after delivery, and during breastfeeding will also be considered where available. This systematic review is being conducted as part of the development of the new AWMF S3 guideline “Neuroimmunological Diseases and the Desire to Have Children.” The review will provide a structured and transparent evidence base for the formulation of evidence-based recommendations concerning family planning, pregnancy, delivery, postpartum care, and breastfeeding in people with neuroimmunological diseases. The systematic review will follow established standards for systematic evidence synthesis and will be preregistered to ensure transparency and reproducibility of the planned methods.
Source: Open Science Framework
Authors: Sandra Thiel, Nadine Bast, Pierre Schumacher, Celine Widera, Sabrina Haben, Isabel Lachner, Karen Dost-Kovalsky, Nadine Steubesand, Tania Kümpfel, Christiane Schneider-Gold, Ilya Ayzenberg, Kalliopi Pitarokoilli, Carolin Schwake, Simon Faissner, Ruth Schneider, Achim Berthele, Franziska Thaler, Andreas Meisel, Amani Suboh, Sarah Hoffmann, Heinz Wiendl, Sibylle Frase, Judith Eisele, Cora Koch, Charlotte Schubert, Frank Leypoldt, Ilka Kleffner, Lara Diem, Veronika Kana, Marina Herwerth, Barbara Kornek, Gabriel Bsteh, Isabell Haase, Laura Lotz, Melanie Henes, Waltraut Merz, Regina Trollmann, Peter Huppke, Anke Diemert, Norbert Teig, Ute Meyer, Alexandra Bielfeld, Daniela Wendt, Simone Sengstock, Judith Haas, Claudia Schlemminger, Lea Gerischer, Matthias Fuchs, Alexandra Kessmeyer, Greta Dünow, Nina Blum, Stephanie Guder, Alix Bertrand, Nina Timmesfeld, Kerstin Hellwig
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225639670