ID-SCAN: a functional MRI protocol for neurophenomenological phenotyping of dissociative identity disorder without trauma provocation
Year: 2026
Type: article
Abstract: Background: Dissociative identity disorder (DID) is a trauma-related dissociative disorder in which two or more identity-agents recur within one person, each experiencing and evaluating itself and its surroundings. Most existing neuroimaging paradigms rely on symptom provocation using trauma-related autobiographical material. Identity-agent effects that are independent of symptom provocation need to be disentangled from emotional responses to trauma-related material and from the co-consciousness of other identity-agents. Objective: To introduce ID-SCAN (Identity-agent State Characterisation and Analysis), a functional MRI protocol without trauma provocation for within-person neurophenomenological characterisation of identity-agent expression and switching, and to test its feasibility in a co-conscious case. Method: A woman with DID living with persistent co-consciousness between two identity-agents (Adu and Ado) completed two fMRI tasks: identity-cued evaluation of identical insect photographs the agents made sense of in opposite ways, and trait judgments about self, the other agent and a shared intimate other. Within-person analyses combined Bayesian general linear modelling, generalised psychophysiological interaction, representational similarity analysis and a pooled identity-cue switching analysis, with cross-task overlap providing a task-general baseline. Results: Adu and Ado made sense of the same insect photographs differently. Ado showed greater activation in striato-thalamic regions, whereas Adu showed greater activation in the amygdala and in the orbitofrontal and medial prefrontal cortex; the two also differed in task-evoked connectivity. Adu-as-self and Ado-as-self occupied separable positions within self-referential regions. Cue-locked activity differed by switch direction, with greater reconfiguration when switching to the less-foregrounded Adu. Cross-task overlap localised to posterior visual and dorsal parietal cortex. Conclusions: Two co-conscious identity-agents showed distinct, convergent neurophenomeno-logical signatures of expression and switching in this single case without trauma provocation. ID-SCAN suits single-case and groupwise, simulator-controlled designs and provides a candidate framework for future longitudinal and treatment-related research whose test–retest reliability and clinical sensitivity remain to be established. ID-SCAN is an identity-cued functional MRI protocol, without trauma provocation, for within-person neurophenomenological characterisation of identity-agent expression and switching in dissociative identity disorder.Two co-conscious identity-agents made sense of identical images in opposite ways and occupied separable self-like positions within self-referential regions, with a direction-dependent switching asymmetry.By avoiding symptom provocation and trauma-related recall, ID-SCAN offers a clinically less burdensome foundation for cohort, simulator-controlled and treatment-tracking research on trauma-related dissociation. ID-SCAN is an identity-cued functional MRI protocol, without trauma provocation, for within-person neurophenomenological characterisation of identity-agent expression and switching in dissociative identity disorder. Two co-conscious identity-agents made sense of identical images in opposite ways and occupied separable self-like positions within self-referential regions, with a direction-dependent switching asymmetry. By avoiding symptom provocation and trauma-related recall, ID-SCAN offers a clinically less burdensome foundation for cohort, simulator-controlled and treatment-tracking research on trauma-related dissociation.
Source: Figshare
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225830288
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