Work

Striatal dopamine availability peaks in adulthood and undergoes age-dependent modulation

Year: 2026

Type: preprint

Abstract: Age is a risk factor for several psychiatric disorders. An adolescent peak in striatal dopamine availability is thought to contribute to the neuropsychiatric vulnerability. However, the lifespan trajectory of striatal dopamine release capacity is undefined in most species. Here, we measured lifespan trajectories of striatal dopamine in primates and rodents and identified a delayed developmental peak in adulthood and age-dependent changes in dopamine release regulation by GABA and acetylcholine across species.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.11.10.765699

Authors: Samantha R White, J Hoon Shin, Hannah Goldbach, Marta Andujar, Evan S Swanson, Racehele Rimondini, Abigail L Carr, Lucy G Anderson, Sydney E Cerveny, Peyton Q Harmon, Anna Claire Tangen, Kenneth A Pelkey, Reza Azadi, Alexander C Cummins, Chris J McBain, Bruno Averbeck, Veronica A Alvarez

Institutions: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7225834339

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